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BCN HEALTH presents three communications in the congress ILC assessing clinical and economic burden of patients with HDV coinfection and HBV monoinfection in Spain

BCN HEALTH presents the poster "Increased baseline comorbidity burden including liver severity among HDV/HBV coinfection versus HBV monoinfection patients – analysis from National Hospital Discharge Records Database in Spain"

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BCN HEALTH presents the poster "Increased baseline comorbidity burden including liver severity among HDV/HBV coinfection versus HBV monoinfection patients – analysis from National Hospital Discharge Records Database in Spain" on a retrospective study that included records of HDV coinfection and HBV monoinfection patients admitted to hospitals in Spain between 2000 and 2019. The objectives of the study were to compare baseline characteristics of adult patients with HDV/HBV vs. hepatitis B monoinfection in Spain. This study reported 12,317 patients diagnosed with HDV/HBV or HBV, of which 3,079 met the inclusion criteria - 159 HDV/HBV and 2,920 HBV only patients. HDV/HBV patients were significantly younger than HBV only patients (mean age 42.7 vs. 46.6 years). The male to female ratio (roughly 3:1) was similar across the two cohorts. This study concludes that HDV coinfected patients had greater comorbidities and significantly higher liver disease severity than HBV monoinfected patients. These findings underscore the need for early screening and diagnosis, and eventual treatment of HDV to mitigate future disease progression.

The poster "Rising clinical and economic burden among hospitalized HDV/HBV coinfected patients in Spain" shows the results of the analysis of 12,317 records of patients diagnosed with HDV/HBV or HBV only in Spain extracted from a database containing records from 192 private and 313 public centres. This study aimed to assess the epidemiology, baseline characteristics, healthcare resource use and costs among hospitalized HDV/HBV coinfected patients in Spain between Jan 2000 and Dec 2019. The mean age of the patients under study was 42.7 years and the 73.6% of them were males. The results of the study highlight that hospitalized Spain HDV/HBV patients have a high comorbidity burden. Total healthcare costs are high, with inpatient costs as the primary driver, posing a high economic burden. Novel treatment strategies are needed to improve patient outcomes and reduce the economic burden among HDV/HBV coinfected patients in Spain.

Finally, the poster "Higher healthcare resource use and costs among patients with HDV coinfection versus HBV monoinfection in Spain – results from National Hospital Database" summarises the results obtained after analysing data on patients diagnosed with HDV coinfection vs HBV monoinfection in Spain between 2000 and 2019. HDV and HBV cohorts were age- and gender-matched (1:3) to evaluate incremental differences in resource use and costs. This study aimed to compares baseline comorbidities, healthcare resource use and costs in a matched cohort of adult patients with HDV coinfection vs HBV monoinfection in a national hospital database in Spain. The study reported 12,317 patients diagnosed with HDV or HBV, matching yielded at 125 HDV and 312 HBV patients. The male to female ratio was significantly higher in HBV (~10:1) vs HDV (~5:1) patients. This study concludes that HDV coinfected had significantly greater comorbidities, resource use and costs than HBV monoinfected patients. These findings further confirm the need for early screening and diagnosis, and treatment of HDV to alleviate disease progression.