It’s “All-go” with Oligos: Challenges and Opportunities in LC-MS of Therapeutic
The episode will focus on oligonucleotide LC-MS, covering key challenges, the critical importance of assay sensitivity, and various analytical approaches and technologies that are currently used, have been used, or are being developed.
In this podcast, Robert MacNeill, Professor Michael Bartlett of the University of Georgia and Dr. Guilherme Guimaraes of Biogen, will focus on oligonucleotide LC-MS covering the exciting key challenges, the pivotal nature of sensitivity in such assays, and the various analytical approaches and technologies that have been used, currently in use or being developed.
The episode explores the following:
- How recent liquid chromatographic and mass spectral innovations have impacted the bioanalysis of these drug modalities
- Where innovation is taking us particularly in terms of the increasing profile of high-resolution mass spectrometry and the push toward chromatographic miniaturization
Listen to the episode here.
Stay tuned for more podcasts in our Pharmaron DMPK Insights Series! Visit our website to learn more.