ORYZON reports results and corporate update for quarter ended March 31, 2022

Oryzon Genomics, S.A., a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, today reported financial results for the first quarter of 2022 and provided an update on recent developments.

Dr Carlos Buesa, Oryzon’s Chief Executive Officer, said: “We continued to make strong progress on our clinical pipeline this quarter. In oncology, we obtained approval from the U.S. Food and Drug Administration (FDA) for our Investigational New Drug application (IND) for FRIDA, a Phase Ib trial with iadademstat in combination with gilteritinib in relapsed/refractory acute myeloid leukemia patients harboring a FMS-like tyrosine kinase mutation”.

“In CNS, we also made strong progress. We are actively recruiting patients into the Phase IIb PORTICO trial with vafidemstat in Borderline Personality Disorder (BPD) in the USA, Spain, Germany, Bulgaria and Serbia. Vafidemstat’s Phase IIb trial in schizophrenia, called EVOLUTION, has continued to enroll patients. Furthermore, we are working with the most prestigious key opinion leaders in the space to finalize the design of HOPE, the first randomized Phase I/II personalized medicine trial with an LSD1 inhibitor, in Kabuki Syndrome (KS) patients, which we expect to start in the first half of 2022. Oryzon has further strengthened its presence in the US with the appointment of Douglas V. Faller, MD, PhD as Global Chief Medical Officer, and Dr Ana Limón as SVP in Clinical Development and Global Medical Affairs, both based in Boston. We finished this first quarter with a solid cash position of $28.0 million, which provides funding for further development of our exciting pipeline until 1H2023.”

 

More information on the file attached.